Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
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چکیده
منابع مشابه
Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein response (UPR), a key mechanism linking supply of excess nutrients to insulin resistance and type 2 diabetes in obesity. The ER harbors proteins that participate in protein folding...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2014
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201302561